Temporal trends, risk factors and outcomes of infections due to extended-spectrum β-lactamase producing Enterobacterales in Swiss solid organ transplant recipients between 2012 and 2018

Kohler, Philipp; Wolfensberger, Aline; Stampf, Susanne; Brönnimann, Andreas; Boggian, Katia; van Delden, Christian; Favre, Melody; Hirzel, Cédric; Khanna, Nina; Kuster, Stefan P; Manuel, Oriol; Neofytos, Dionysios; Ragozzino, Silvio; Schreiber, Peter W; Walti, Laura; Mueller, Nicolas J; Swiss Transplant Cohort Study

doi:10.1186/s13756-021-00918-7

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Kohler, P., Wolfensberger, A., Stampf, S., Brönnimann, A., Boggian, K., van Delden, C., Favre, M., Hirzel, C., Khanna, N., Kuster, S. P., Manuel, O., Neofytos, D., Ragozzino, S., Schreiber, P. W., Walti, L., Mueller, N. J., & Swiss Transplant Cohort Study. (2021). Temporal trends, risk factors and outcomes of infections due to extended-spectrum β-lactamase producing Enterobacterales in Swiss solid organ transplant recipients between 2012 and 2018. Antimicrobial Resistance and Infection Control, 10, 50. https://doi.org/10.1186/s13756-021-00918-7

Abstract

BACKGROUND

The burden of antimicrobial resistance is high in solid organ transplant (SOT) recipients. Among Swiss SOT recipients, we assessed temporal trends of ESBL-producing Enterobacterales (ESBL-E), identified risk factors for ESBL-E, and assessed the impact of resistance on patient outcome.

METHODS

Data from the Swiss Transplant Cohort Study (STCS), a nationwide prospective cohort of SOT-recipients, were analysed. Temporal trends were described for ESBL-detection among Escherichia coli and non-Escherichia coli. In a nested cas