Publication: A randomised, single-blind, dose-range study to assess the immunogenicity and safety of a cell-culture-derived A/H1N1 influenza vaccine in adult and elderly populations
A randomised, single-blind, dose-range study to assess the immunogenicity and safety of a cell-culture-derived A/H1N1 influenza vaccine in adult and elderly populations
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Hatz, C., Cramer, J. P., Vertruyen, A., Schwarz, T. F., von Sonnenburg, F., Borkowski, A., Lattanzi, M., Hilbert, A. K., Cioppa, G. D., & Leroux-Roels, G. (2012). A randomised, single-blind, dose-range study to assess the immunogenicity and safety of a cell-culture-derived A/H1N1 influenza vaccine in adult and elderly populations. Vaccine, 30(32), 4820–4827. https://doi.org/10.1016/j.vaccine.2012.05.013
Abstract
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Abstract
BACKGROUND: Modern cell-culture production techniques and the use of adjuvants helps to ensure that the global demand for pandemic influenza vaccine can be met. This study aimed to assess the immunogenicty and safety profiles of various cell-culture-derived A/H1N1 pandemic vaccine formulations in healthy adult and elderly subjects. METHODS: Adult (18-60 years) subjects (n=544) received vaccine either containing 3.75 μg of antigen with half the standard dose of MF59 (Novartis Vaccines and Diagnostics) adjuvant, 7.5 μg antigen with a fu
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Creators (Authors)
- Hatz, Christoph
- Cramer, Jakob P
- Vertruyen, André
- Schwarz, Tino F
- von Sonnenburg, Frank
- Borkowski, Astrid
- Lattanzi, Maria
- Hilbert, Anne Katrin
- Cioppa, Giovanni Della
- Leroux-Roels, Geert
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Citations
Hatz, C., Cramer, J. P., Vertruyen, A., Schwarz, T. F., von Sonnenburg, F., Borkowski, A., Lattanzi, M., Hilbert, A. K., Cioppa, G. D., & Leroux-Roels, G. (2012). A randomised, single-blind, dose-range study to assess the immunogenicity and safety of a cell-culture-derived A/H1N1 influenza vaccine in adult and elderly populations. Vaccine, 30(32), 4820–4827. https://doi.org/10.1016/j.vaccine.2012.05.013
