Publication: Oncotargets in different renal cancer subtypes
Oncotargets in different renal cancer subtypes
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Moch, H., Montironi, R., Lopez-Beltran, A., Cheng, L., & Mischo, A. (2015). Oncotargets in different renal cancer subtypes. Current Drug Targets, 16(2), 125–135. https://doi.org/10.2174/1389450116666150126110632
Abstract
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Renal cell cancer is a heterogeneous group of cancers with different histologic subtypes. The majority of renal tumors in adults are clear cell renal cell carcinomas, which are characterized by von Hippel- Lindau (VHL) gene alterations. Recent advances in defining the genetic landscape of renal cancer has shown the genetic heterogeneity of clear cell renal cell carcinomas (ccRCC) and the presence of at least 3 additional ccRCC tumor suppressor genes on chromosome 3p. Due to inactivation of VHL, renal cancer cells produce the HIF-respo
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- Moch, Holger
- Montironi, Rodolfo
- Lopez-Beltran, Antonio
- Cheng, Liang
- Mischo, Axel
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Moch, H., Montironi, R., Lopez-Beltran, A., Cheng, L., & Mischo, A. (2015). Oncotargets in different renal cancer subtypes. Current Drug Targets, 16(2), 125–135. https://doi.org/10.2174/1389450116666150126110632