Publication: Activation of cryptic splicing in bovine WDR19 is associated with reduced semen quality and male fertility
Activation of cryptic splicing in bovine WDR19 is associated with reduced semen quality and male fertility
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Hiltpold, M., Niu, G., Kadri, N. K., Crysnanto, D., Fang, Z.-H., Spengeler, M., Schmitz-Hsu, F., Fuerst, C., Schwarzenbacher, H., Seefried, F. R., Seehusen, F., Witschi, U., Schnieke, A., Fries, R., Bollwein, H., Flisikowski, K., & Pausch, H. (2020). Activation of cryptic splicing in bovine WDR19 is associated with reduced semen quality and male fertility. PLoS Genetics, 16(5), e1008804. https://doi.org/10.1371/journal.pgen.1008804
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Abstract
Cattle are ideally suited to investigate the genetics of male reproduction, because semen quality and fertility are recorded for all ejaculates of artificial insemination bulls. We analysed 26,090 ejaculates of 794 Brown Swiss bulls to assess ejaculate volume, sperm concentration, sperm motility, sperm head and tail anomalies and insemination success. The heritability of the six semen traits was between 0 and 0.26. Genome-wide association testing on 607,511 SNPs revealed a QTL on bovine chromosome 6 that was associated with sperm moti
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- Hiltpold, Maya
- Niu, Guanglin
- Kadri, Naveen Kumar
- Crysnanto, Danang
- Fang, Zih-Hua
- Schmitz-Hsu, Fritz
- Seehusen, Frauke
- Witschi, Ulrich
- Schnieke, Angelika
- Fries, Ruedi
- Bollwein, Heiner
- Flisikowski, Krzysztof
- Pausch, Hubert
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Hiltpold, M., Niu, G., Kadri, N. K., Crysnanto, D., Fang, Z.-H., Spengeler, M., Schmitz-Hsu, F., Fuerst, C., Schwarzenbacher, H., Seefried, F. R., Seehusen, F., Witschi, U., Schnieke, A., Fries, R., Bollwein, H., Flisikowski, K., & Pausch, H. (2020). Activation of cryptic splicing in bovine WDR19 is associated with reduced semen quality and male fertility. PLoS Genetics, 16(5), e1008804. https://doi.org/10.1371/journal.pgen.1008804
