Publication: Efficient characterization of high-dimensional parameter spaces for systems biology
Efficient characterization of high-dimensional parameter spaces for systems biology
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Zamora-Sillero, E., Hafner, M., Ibig, A., Stelling, J., & Wagner, A. (2011). Efficient characterization of high-dimensional parameter spaces for systems biology. BMC Systems Biology, 5, 142. https://doi.org/10.1186/1752-0509-5-142
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BACKGROUND: A biological system's robustness to mutations and its evolution are influenced by the structure of its viable space, the region of its space of biochemical parameters where it can exert its function. In systems with a large number of biochemical parameters, viable regions with potentially complex geometries fill a tiny fraction of the whole parameter space. This hampers explorations of the viable space based on "brute force" or Gaussian sampling. RESULTS: We here propose a novel algorithm to characterize viable spaces effi
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- Zamora-Sillero, E
- Hafner, M
- Ibig, A
- Stelling, J
- Wagner, A
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Zamora-Sillero, E., Hafner, M., Ibig, A., Stelling, J., & Wagner, A. (2011). Efficient characterization of high-dimensional parameter spaces for systems biology. BMC Systems Biology, 5, 142. https://doi.org/10.1186/1752-0509-5-142
