Publication: A large-scale, in vivo transcription factor screen defines bivalent chromatin as a key property of regulatory factors mediating Drosophila wing development
A large-scale, in vivo transcription factor screen defines bivalent chromatin as a key property of regulatory factors mediating Drosophila wing development
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Schertel, C., Albarca, M., Rockel-Bauer, C., Kelley, N. W., Bischof, J., Hens, K., van Nimwegen, E., Basler, K., & Deplancke, B. (2015). A large-scale, in vivo transcription factor screen defines bivalent chromatin as a key property of regulatory factors mediating Drosophila wing development. Genome Research, 25(4), 514–523. https://doi.org/10.1101/gr.181305.114
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Transcription factors (TFs) are key regulators of cell fate. The estimated 755 genes that encode DNA binding domain-containing proteins comprise ∼5% of all Drosophila genes. However, the majority has remained uncharacterized so far due to the lack of proper genetic tools. We generated 594 site-directed transgenic Drosophila lines that contain integrations of individual UAS-TF constructs to facilitate spatiotemporally controlled misexpression in vivo. All transgenes were expressed in the developing wing, and two-thirds induced specific
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- Schertel, Claus
- Albarca, Monica
- Rockel-Bauer, Claudia
- Kelley, Nicholas W
- Bischof, Johannes
- Hens, Korneel
- van Nimwegen, Erik
- Deplancke, Bart
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Schertel, C., Albarca, M., Rockel-Bauer, C., Kelley, N. W., Bischof, J., Hens, K., van Nimwegen, E., Basler, K., & Deplancke, B. (2015). A large-scale, in vivo transcription factor screen defines bivalent chromatin as a key property of regulatory factors mediating Drosophila wing development. Genome Research, 25(4), 514–523. https://doi.org/10.1101/gr.181305.114
