Computed tomography perfusion imaging of renal cell carcinoma: systematic comparison with histopathological angiogenic and prognostic markers

Reiner, Caecilia S; Roessle, Matthias; Thiesler, Thore; Eberli, Daniel; Klotz, Ernst; Frauenfelder, Thomas; Sulser, Tullio; Moch, Holger; Alkadhi, Hatem

doi:10.1097/RLI.0b013e31827c63a3

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Reiner, C. S., Roessle, M., Thiesler, T., Eberli, D., Klotz, E., Frauenfelder, T., Sulser, T., Moch, H., & Alkadhi, H. (2013). Computed tomography perfusion imaging of renal cell carcinoma: systematic comparison with histopathological angiogenic and prognostic markers. Investigative Radiology, 48, 183–191. https://doi.org/10.1097/RLI.0b013e31827c63a3

Abstract

PURPOSE: The aim of this study was to systematically analyze the correlation between computed tomography (CT) perfusion and histopathological angiogenic and prognostic markers in patients with renal cell carcinoma (RCC). MATERIAL AND METHODS: Fifteen patients (12 men; mean age, 64.5 ± 9.4 years) with RCC underwent contrast-enhanced CT perfusion imaging (scan range, 10 cm; scan time, 40 seconds; dual-source 128-section CT) 1 day before surgery. The procedure for surgical specimen processing was modified to obtain an exact match with CT