Publication: Effect of polyethylene-glycolated carboxyhemoglobin on renal microcirculation in a rat model of hemorrhagic shock
Effect of polyethylene-glycolated carboxyhemoglobin on renal microcirculation in a rat model of hemorrhagic shock
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Guerci, P., Ergin, B., Kapucu, A., Hilty, M. P., Jubin, R., Bakker, J., & Ince, C. (2019). Effect of polyethylene-glycolated carboxyhemoglobin on renal microcirculation in a rat model of hemorrhagic shock. Anesthesiology, 131(5), 1110–1124. https://doi.org/10.1097/aln.0000000000002932
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BACKGROUND: Primary resuscitation fluid to treat hemorrhagic shock remains controversial. Use of hydroxyethyl starches raised concerns of acute kidney injury. Polyethylene-glycolated carboxyhemoglobin, which has carbon monoxide-releasing molecules and oxygen-carrying properties, was hypothesized to sustain cortical renal microcirculatory PO2 after hemorrhagic shock and reduce kidney injury. METHODS: Anesthetized and ventilated rats (n = 42) were subjected to pressure-controlled hemorrhagic shock for 1 h. Renal cortical PO2 was measure
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- Guerci, Philippe
- Ergin, Bulent
- Kapucu, Aysegul
- Hilty, Matthias P
- Jubin, Ronald
- Bakker, Jan
- Ince, Can
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Guerci, P., Ergin, B., Kapucu, A., Hilty, M. P., Jubin, R., Bakker, J., & Ince, C. (2019). Effect of polyethylene-glycolated carboxyhemoglobin on renal microcirculation in a rat model of hemorrhagic shock. Anesthesiology, 131(5), 1110–1124. https://doi.org/10.1097/aln.0000000000002932
