Publication: A cell culture system for the induction of Mallory bodies: Mallory bodies and aggresomes represent different types of inclusion bodies
A cell culture system for the induction of Mallory bodies: Mallory bodies and aggresomes represent different types of inclusion bodies
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Hirano, K., Guhl, B., Roth, J., & Ziak, M. (2009). A cell culture system for the induction of Mallory bodies: Mallory bodies and aggresomes represent different types of inclusion bodies. Histochemistry and Cell Biology, 132(3), 293–304. https://doi.org/10.1007/s00418-009-0598-9
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Mallory bodies (MBs) represent keratin-rich inclusion bodies observed in human alcoholic liver disease and in several chronic non-alcoholic liver diseases. The mechanism of their formation and their relationship to other inclusion bodies such as aggresomes is incompletely understood. We could induce keratin aggregates typical of MBs in cultured clone 9 rat hepatocytes by transgenic expression of wild-type and mutant aquaporin2 or α1-antitrypsin and under various forms of other cellular stress. By immunocytochemical analysis, p62 and p
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- Hirano, Kiyoko
- Guhl, Bruno
- Roth, Jürgen
- Ziak, Martin
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Hirano, K., Guhl, B., Roth, J., & Ziak, M. (2009). A cell culture system for the induction of Mallory bodies: Mallory bodies and aggresomes represent different types of inclusion bodies. Histochemistry and Cell Biology, 132(3), 293–304. https://doi.org/10.1007/s00418-009-0598-9
