Publication: Recurrent Herpes Zoster Ophthalmicus in a Patient With a Novel Toll-Like Receptor 3 Variant Linked to Compromised Activation Capacity in Fibroblasts
Recurrent Herpes Zoster Ophthalmicus in a Patient With a Novel Toll-Like Receptor 3 Variant Linked to Compromised Activation Capacity in Fibroblasts
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Liang, F., Glans, H., Enoksson, S. L., Kolios, A. G. A., Loré, K., & Nilsson, J. (2020). Recurrent Herpes Zoster Ophthalmicus in a Patient With a Novel Toll-Like Receptor 3 Variant Linked to Compromised Activation Capacity in Fibroblasts. Journal of Infectious Diseases, 221(8), 1295–1303. https://doi.org/10.1093/infdis/jiz229
Abstract
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BACKGROUND:
Herpes zoster ophthalmicus occurs primarily in elderly or immunocompromised individuals after reactivation of varicella zoster virus (VZV). Recurrences of zoster ophthalmicus are uncommon because the reactivation efficiently boosts anti-VZV immunity. A 28-year-old female presented to our clinic with a history of multiple recurrences of zoster ophthalmicus. METHODS:
Whole-exome sequencing (WES), analyses of VZV T-cell immunity, and pathogen recognition receptor function in primary antigen-presenting cells (APCs) and fibro
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Creators (Authors)
- Liang, Frank
- Glans, Hedvig
- Enoksson, Sara Lind
- Kolios, Antonios G A
- Loré, Karin
- Nilsson, Jakob
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Liang, F., Glans, H., Enoksson, S. L., Kolios, A. G. A., Loré, K., & Nilsson, J. (2020). Recurrent Herpes Zoster Ophthalmicus in a Patient With a Novel Toll-Like Receptor 3 Variant Linked to Compromised Activation Capacity in Fibroblasts. Journal of Infectious Diseases, 221(8), 1295–1303. https://doi.org/10.1093/infdis/jiz229