Publication: αENaC-Mediated Lithium Absorption Promotes Nephrogenic Diabetes Insipidus
αENaC-Mediated Lithium Absorption Promotes Nephrogenic Diabetes Insipidus
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Christensen, B. M., Mercier Zuber, A., Loffing, J., Stehle, J. C., Deen, P. M. T., Rossier, B. C., & Hummler, E. (2011). αENaC-Mediated Lithium Absorption Promotes Nephrogenic Diabetes Insipidus. Journal of the American Society of Nephrology (JASN), 22, 253–261. https://doi.org/10.1681/ASN.2010070734
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Lithium-induced nephrogenic diabetes insipidus (NDI) is accompanied by polyuria, downregulation of aquaporin 2 (AQP2), and cellular remodeling of the collecting duct (CD). The amiloride-sensitive epithelial sodium channel (ENaC) is a likely candidate for lithium entry. Here, we subjected transgenic mice lacking αENaC specifically in the CD (knockout [KO] mice) and littermate controls to chronic lithium treatment. In contrast to control mice, KO mice did not markedly increase their water intake. Furthermore, KO mice did not demonstrate
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- Christensen, B M
- Mercier Zuber, A
- Loffing, J
- Stehle, J C
- Deen, P M T
- Rossier, B C
- Hummler, E
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Christensen, B. M., Mercier Zuber, A., Loffing, J., Stehle, J. C., Deen, P. M. T., Rossier, B. C., & Hummler, E. (2011). αENaC-Mediated Lithium Absorption Promotes Nephrogenic Diabetes Insipidus. Journal of the American Society of Nephrology (JASN), 22, 253–261. https://doi.org/10.1681/ASN.2010070734
