Interplay with the Mre11-Rad50-Nbs1 complex and phosphorylation by GSK3β implicate human B-Myb in DNA-damage signaling

Henrich, Sarah Marie; Usadel, Clemens; Werwein, Eugen; Burdova, Kamila; Janscak, Pavel; Ferrari, Stefano; Hess, Daniel; Klempnauer, Karl-Heinz

doi:10.1038/srep41663

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Henrich, S. M., Usadel, C., Werwein, E., Burdova, K., Janscak, P., Ferrari, S., Hess, D., & Klempnauer, K.-H. (2017). Interplay with the Mre11-Rad50-Nbs1 complex and phosphorylation by GSK3β implicate human B-Myb in DNA-damage signaling. Scientific Reports, 7, 41663. https://doi.org/10.1038/srep41663

Abstract

B-Myb, a highly conserved member of the Myb transcription factor family, is expressed ubiquitously in proliferating cells and controls the cell cycle dependent transcription of G2/M-phase genes. Deregulation of B-Myb has been implicated in oncogenesis and loss of genomic stability. We have identified B-Myb as a novel interaction partner of the Mre11-Rad50-Nbs1 (MRN) complex, a key player in the repair of DNA double strand breaks. We show that B-Myb directly interacts with the Nbs1 subunit of the MRN complex and is recruited transientl