Publication: Adjuvant mitotane versus surveillance in low-grade, localised adrenocortical carcinoma (ADIUVO): an international, multicentre, open-label, randomised, phase 3 trial and observational study
Adjuvant mitotane versus surveillance in low-grade, localised adrenocortical carcinoma (ADIUVO): an international, multicentre, open-label, randomised, phase 3 trial and observational study
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Terzolo, M., Fassnacht, M., Perotti, P., Libé, R., Kastelan, D., Lacroix, A., Arlt, W., Haak, H. R., Loli, P., Decoudier, B., Lasolle, H., Quinkler, M., Haissaguerre, M., Chabre, O., Caron, P., Stigliano, A., Giordano, R., Zatelli, M. C., Bancos, I., … et al. (2023). Adjuvant mitotane versus surveillance in low-grade, localised adrenocortical carcinoma (ADIUVO): an international, multicentre, open-label, randomised, phase 3 trial and observational study. The Lancet. Diabetes & Endocrinology, 11(10), 720–730. https://doi.org/10.1016/S2213-8587(23)00193-6
Abstract
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BACKGROUND Adjuvant treatment with mitotane is commonly used after resection of adrenocortical carcinoma; however, treatment remains controversial, particularly if risk of recurrence is not high. We aimed to assess the efficacy and safety of adjuvant mitotane compared with surveillance alone following complete tumour resection in patients with adrenocortical carcinoma considered to be at low to intermediate risk of recurrence.
METHODS ADIUVO was a multicentre, open-label, parallel, randomised, phase 3 trial done in 23 centres across
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- Terzolo, Massimo
- Fassnacht, Martin
- Perotti, Paola
- Libé, Rossella
- Kastelan, Darko
- Lacroix, André
- Arlt, Wiebke
- Haak, Harm Reinout
- Loli, Paola
- Decoudier, Bénédicte
- Lasolle, Helene
- Quinkler, Marcus
- Haissaguerre, Magalie
- Chabre, Olivier
- Caron, Philippe
- Stigliano, Antonio
- Giordano, Roberta
- Zatelli, Maria Chiara
- Bancos, Irina
- Fragoso, Maria Candida Barisson Villares
- Canu, Letizia
- Luconi, Michaela
- Puglisi, Soraya
- Basile, Vittoria
- Reimondo, Giuseppe
- Kroiss, Matthias
- Megerle, Felix
- Hahner, Stefanie
- Kimpel, Otilia
- Dusek, Tina
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Terzolo, M., Fassnacht, M., Perotti, P., Libé, R., Kastelan, D., Lacroix, A., Arlt, W., Haak, H. R., Loli, P., Decoudier, B., Lasolle, H., Quinkler, M., Haissaguerre, M., Chabre, O., Caron, P., Stigliano, A., Giordano, R., Zatelli, M. C., Bancos, I., … et al. (2023). Adjuvant mitotane versus surveillance in low-grade, localised adrenocortical carcinoma (ADIUVO): an international, multicentre, open-label, randomised, phase 3 trial and observational study. The Lancet. Diabetes & Endocrinology, 11(10), 720–730. https://doi.org/10.1016/S2213-8587(23)00193-6
