Publication: Mutant SF3B1 promotes malignancy in PDAC
Mutant SF3B1 promotes malignancy in PDAC
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Simmler, P., Ioannidi, E. I., Mengis, T., Marquart, K. F., Asawa, S., Van-Lehmann, K., Kahles, A., Thomas, T., Schwerdel, C., Aceto, N., Rätsch, G., Stoffel, M., & Schwank, G. (2023). Mutant SF3B1 promotes malignancy in PDAC. ELife, 12, e80683. https://doi.org/10.7554/eLife.80683
Abstract
Abstract
Abstract
The splicing factor SF3B1 is recurrently mutated in various tumors, including pancreatic ductal adenocarcinoma (PDAC). The impact of the hotspot mutation SF3B1$^{K700E}$ on the PDAC pathogenesis, however, remains elusive. Here, we demonstrate that Sf3b1$^{K700E}$ alone is insufficient to induce malignant transformation of the murine pancreas, but that it increases aggressiveness of PDAC if it co-occurs with mutated KRAS and p53. We further show that Sf3b1$^{K700E}$
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Creators (Authors)
- Simmler, Patrik
- Ioannidi, Eleonora I
- Mengis, Tamara
- Marquart, Kim Fabiano
- Asawa, Simran
- Van-Lehmann, Kjong
- Kahles, Andre
- Thomas, Tinu
- Schwerdel, Cornelia
- Aceto, Nicola
- Rätsch, Gunnar
- Stoffel, Markus
- Schwank, Gerald
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Simmler, P., Ioannidi, E. I., Mengis, T., Marquart, K. F., Asawa, S., Van-Lehmann, K., Kahles, A., Thomas, T., Schwerdel, C., Aceto, N., Rätsch, G., Stoffel, M., & Schwank, G. (2023). Mutant SF3B1 promotes malignancy in PDAC. ELife, 12, e80683. https://doi.org/10.7554/eLife.80683
