Publication: DNA2 cooperates with the WRN and BLM RecQ helicases to mediate long-range DNA-end resection in human cells
DNA2 cooperates with the WRN and BLM RecQ helicases to mediate long-range DNA-end resection in human cells
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Sturzenegger, A., Burdova, K., Kanagaraj, R., Levikova, M., Pinto, C., Cejka, P., & Janscak, P. (2014). DNA2 cooperates with the WRN and BLM RecQ helicases to mediate long-range DNA-end resection in human cells. Journal of Biological Chemistry, 289, 27314–27326. https://doi.org/10.1074/jbc.M114.578823
Abstract
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Abstract
The 5'-3' resection of DNA ends is a prerequisite for repair of DNA double-strand breaks by homologous recombination, microhomology-mediated end joining and single-strand annealing. Recent studies in yeast have shown that following an initial DNA-end processing by the Mre11-Rad50-Xrs2 complex and Sae2, extension of resection tracts is mediated either by Exonuclease 1 or by combined activities of the RecQ-family DNA helicase Sgs1 and the helicase/endonuclease Dna2. Although human DNA2 was shown to cooperate with the BLM helicase to cat
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Creators (Authors)
- Sturzenegger, Andreas
- Burdova, Kamila
- Kanagaraj, Radhakrishnan
- Levikova, Maryna
- Pinto, Cosimo
- Cejka, Petr
- Janscak, Pavel
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Citations
Sturzenegger, A., Burdova, K., Kanagaraj, R., Levikova, M., Pinto, C., Cejka, P., & Janscak, P. (2014). DNA2 cooperates with the WRN and BLM RecQ helicases to mediate long-range DNA-end resection in human cells. Journal of Biological Chemistry, 289, 27314–27326. https://doi.org/10.1074/jbc.M114.578823
