Publication: Africa-specific human genetic variation near CHD1L associates with HIV-1 load
Africa-specific human genetic variation near CHD1L associates with HIV-1 load
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McLaren, P. J., Porreca, I., Iaconis, G., Mok, H. P., Mukhopadhyay, S., Karakoc, E., Cristinelli, S., Pomilla, C., Bartha, I., Thorball, C. W., Tough, R. H., Angelino, P., Kiar, C. S., Carstensen, T., Fatumo, S., Porter, T., Jarvis, I., Skarnes, W. C., Bassett, A., … Trkola, A. (2023). Africa-specific human genetic variation near CHD1L associates with HIV-1 load. Nature, 620, 1025–1030. https://doi.org/10.1038/s41586-023-06370-4
Abstract
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Abstract
HIV-1 remains a global health crisis, highlighting the need to identify new targets for therapies. Here, given the disproportionate HIV-1 burden and marked human genome diversity in Africa, we assessed the genetic determinants of control of set-point viral load in 3,879 people of African ancestries living with HIV-1 participating in the international collaboration for the genomics of HIV. We identify a previously undescribed association signal on chromosome 1 where the peak variant associates with an approximately 0.3 log$_{10}$-trans
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Creators (Authors)
- McLaren, Paul J
- Porreca, Immacolata
- Iaconis, Gennaro
- Mok, Hoi Ping
- Mukhopadhyay, Subhankar
- Karakoc, Emre
- Cristinelli, Sara
- Pomilla, Cristina
- Bartha, István
- Thorball, Christian W
- Tough, Riley H
- Angelino, Paolo
- Kiar, Cher S
- Carstensen, Tommy
- Fatumo, Segun
- Porter, Tarryn
- Jarvis, Isobel
- Skarnes, William C
- Bassett, Andrew
- DeGorter, Marianne K
- Sathya Moorthy, Mohana Prasad
- Tuff, Jeffrey F
- Kim, Eun-Young
- Walter, Miriam
- Simons, Lacy M
- Bashirova, Arman
- Buchbinder, Susan
- Carrington, Mary
- Cossarizza, Andrea
- De Luca, Andrea
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McLaren, P. J., Porreca, I., Iaconis, G., Mok, H. P., Mukhopadhyay, S., Karakoc, E., Cristinelli, S., Pomilla, C., Bartha, I., Thorball, C. W., Tough, R. H., Angelino, P., Kiar, C. S., Carstensen, T., Fatumo, S., Porter, T., Jarvis, I., Skarnes, W. C., Bassett, A., … Trkola, A. (2023). Africa-specific human genetic variation near CHD1L associates with HIV-1 load. Nature, 620, 1025–1030. https://doi.org/10.1038/s41586-023-06370-4
