Publication: Type VII collagen regulates expression of OATP1B3, promotes front-to-rear polarity and increases structural organisation in 3D spheroid cultures of RDEB tumour keratinocytes
Type VII collagen regulates expression of OATP1B3, promotes front-to-rear polarity and increases structural organisation in 3D spheroid cultures of RDEB tumour keratinocytes
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Dayal, J. H. S., Cole, C. L., Pourreyron, C., Watt, S. A., Lim, Y. Z., Salas-Alanis, J. C., Murrell, D. F., McGrath, J. A., Stieger, B., Jahoda, C., Leigh, I. M., & South, A. P. (2014). Type VII collagen regulates expression of OATP1B3, promotes front-to-rear polarity and increases structural organisation in 3D spheroid cultures of RDEB tumour keratinocytes. Journal of Cell Science, 127(Pt 4), 740–751. https://doi.org/10.1242/jcs.128454
Abstract
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Abstract
Type VII collagen is the main component of anchoring fibrils, structures that are integral to basement membrane homeostasis in skin. Mutations in the gene encoding type VII collagen COL7A1 cause recessive dystrophic epidermolysis bullosa (RDEB) an inherited skin blistering condition complicated by frequent aggressive cutaneous squamous cell carcinoma (cSCC). OATP1B3, which is encoded by the gene SLCO1B3, is a member of the OATP (organic anion transporting polypeptide) superfamily responsible for transporting a wide range of endogenous
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- Dayal, Jasbani H S
- Cole, Clare L
- Pourreyron, Celine
- Watt, Stephen A
- Lim, Yok Zuan
- Salas-Alanis, Julio C
- Murrell, Dedee F
- McGrath, John A
- Stieger, Bruno
- Jahoda, Colin
- Leigh, Irene M
- South, Andrew P
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Dayal, J. H. S., Cole, C. L., Pourreyron, C., Watt, S. A., Lim, Y. Z., Salas-Alanis, J. C., Murrell, D. F., McGrath, J. A., Stieger, B., Jahoda, C., Leigh, I. M., & South, A. P. (2014). Type VII collagen regulates expression of OATP1B3, promotes front-to-rear polarity and increases structural organisation in 3D spheroid cultures of RDEB tumour keratinocytes. Journal of Cell Science, 127(Pt 4), 740–751. https://doi.org/10.1242/jcs.128454
