Exposure to the bromodomain inhibitor N-methyl pyrrolidone blocks spermatogenesis in a hormonal and non-hormonal fashion

Khera, Nupur; Ghayor, Chafik; Pavlova, Ekaterina; Atanassova, Nina; Weber, Franz E

doi:10.1016/j.taap.2021.115568

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Khera, N., Ghayor, C., Pavlova, E., Atanassova, N., & Weber, F. E. (2021). Exposure to the bromodomain inhibitor N-methyl pyrrolidone blocks spermatogenesis in a hormonal and non-hormonal fashion. Toxicology and Applied Pharmacology, 423, 115568. https://doi.org/10.1016/j.taap.2021.115568

Abstract

N-methyl pyrrolidone (NMP) is an FDA approved molecule used as an excipient in pharmaceutical industry. Besides having a central role in formulation of drugs, the most important function of any excipient is to guarantee the safety of the medicine during and after its administration. Several studies have shown that exposure to NMP and especially in rats produce a gonadotoxic effect leading to infertility. However, the mechanisms underlying the effect of NMP on male reproduction are unknown. The aim of this study was to assess the repro