Publication: miR-375 gene dosage in pancreatic β-cells: implications for regulation of β-cell mass and biomarker development
miR-375 gene dosage in pancreatic β-cells: implications for regulation of β-cell mass and biomarker development
Date
Date
Date
Citations
Latreille, M., Herrmanns, K., Renwick, N., Tuschl, T., Malecki, M. T., McCarthy, M. I., Owen, K. R., Rülicke, T., & Stoffel, M. (2015). miR-375 gene dosage in pancreatic β-cells: implications for regulation of β-cell mass and biomarker development. Journal of Molecular Medicine, 93(10), 1159–1169. https://doi.org/10.1007/s00109-015-1296-9
Abstract
Abstract
Abstract
MicroRNAs play a crucial role in the regulation of cell growth and differentiation. Mice with genetic deletion of miR-375 exhibit impaired glycemic control due to decreased β-cell and increased α-cell mass and function. The relative importance of these processes for the overall phenotype of miR-375KO mice is unknown. Here, we show that mice overexpressing miR-375 exhibit normal β-cell mass and function. Selective re-expression of miR-375 in β-cells of miR-375KO mice normalizes both, α- and β-cell phenotypes as well as glucose metaboli
Metrics
Downloads
Views
Additional indexing
Creators (Authors)
- Latreille, Mathieu
- Herrmanns, Karolin
- Renwick, Neil
- Tuschl, Thomas
- Malecki, Maciej T
- McCarthy, Mark I
- Owen, Katharine R
- Rülicke, Thomas
- Stoffel, Markus
Volume
Volume
Volume
Number
Number
Number
Page range/Item number
Page range/Item number
Page range/Item number
Page end
Page end
Page end
Item Type
Item Type
Item Type
In collections
Dewey Decimal Classifikation
Dewey Decimal Classifikation
Dewey Decimal Classifikation
Keywords
Language
Language
Language
Publication date
Publication date
Publication date
Date available
Date available
Date available
ISSN or e-ISSN
ISSN or e-ISSN
ISSN or e-ISSN
OA Status
OA Status
OA Status
Free Access at
Free Access at
Free Access at
Publisher DOI
Metrics
Downloads
Views
Citations
Latreille, M., Herrmanns, K., Renwick, N., Tuschl, T., Malecki, M. T., McCarthy, M. I., Owen, K. R., Rülicke, T., & Stoffel, M. (2015). miR-375 gene dosage in pancreatic β-cells: implications for regulation of β-cell mass and biomarker development. Journal of Molecular Medicine, 93(10), 1159–1169. https://doi.org/10.1007/s00109-015-1296-9
