Publication: Mechanisms of haptoglobin protection against hemoglobin peroxidation triggered endothelial damage
Mechanisms of haptoglobin protection against hemoglobin peroxidation triggered endothelial damage
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Schaer, C. A., Deuel, J. W., Bittermann, A. G., Rubio, I. G., Schoedon, G., Spahn, D. R., Wepf, R. A., Vallelian, F., & Schaer, D. J. (2013). Mechanisms of haptoglobin protection against hemoglobin peroxidation triggered endothelial damage. Cell Death and Differentiation, 20(11), 1569–1579. https://doi.org/10.1038/cdd.2013.113
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Abstract
Extracellular hemoglobin (Hb) has been recognized as a disease trigger in hemolytic conditions such as sickle cell disease, malaria, and blood transfusion. In vivo, many of the adverse effects of free Hb can be attenuated by the Hb scavenger acute-phase protein haptoglobin (Hp). The primary physiologic disturbances that can be caused by free Hb are found within the cardiovascular system and Hb-triggered oxidative toxicity toward the endothelium has been promoted as a potential mechanism. The molecular mechanisms of this toxicity as we
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- Schaer, C A
- Deuel, J W
- Bittermann, A G
- Rubio, I G
- Schoedon, G
- Spahn, D R
- Wepf, R A
- Vallelian, F
- Schaer, D J
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Schaer, C. A., Deuel, J. W., Bittermann, A. G., Rubio, I. G., Schoedon, G., Spahn, D. R., Wepf, R. A., Vallelian, F., & Schaer, D. J. (2013). Mechanisms of haptoglobin protection against hemoglobin peroxidation triggered endothelial damage. Cell Death and Differentiation, 20(11), 1569–1579. https://doi.org/10.1038/cdd.2013.113
