Publication: Modular Platform for the Development of Recombinant Hemoglobin Scavenger Biotherapeutics
Modular Platform for the Development of Recombinant Hemoglobin Scavenger Biotherapeutics
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Buzzi, R. M., Owczarek, C. M., Akeret, K., Tester, A., Pereira, N., Butcher, R., Brügger-Verdon, V., Hardy, M. P., Illi, M., Wassmer, A., Vallelian, F., Humar, R., Hugelshofer, M., Buehler, P. W., Gentinetta, T., & Schaer, D. J. (2021). Modular Platform for the Development of Recombinant Hemoglobin Scavenger Biotherapeutics. Molecular Pharmaceutics, 18, 3158–3170. https://doi.org/10.1021/acs.molpharmaceut.1c00433
Abstract
Abstract
Abstract
Cell-free hemoglobin (Hb) is a driver of disease progression in conditions with intravascular or localized hemolysis. Genetic and acquired anemias or emergency medical conditions such as aneurysmal subarachnoid hemorrhage involve tissue Hb exposure. Haptoglobin (Hp) captures Hb in an irreversible protein complex and prevents its pathophysiological contributions to vascular nitric oxide depletion and tissue oxidation. Preclinical proof-of-concept studies suggest that human plasma-derived Hp is a promising therapeutic candidate for seve
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Creators (Authors)
- Owczarek, Catherine M
- Akeret, Kevin
- Tester, Andrea
- Pereira, Natasha
- Butcher, Rebecca
- Brügger-Verdon, Valérie
- Hardy, Matthew P
- Illi, Marlies
- Wassmer, Andreas
- Vallelian, Florence
- Humar, Rok
- Hugelshofer, Michael
- Buehler, Paul W
- Gentinetta, Thomas
- Schaer, Dominik J
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Buzzi, R. M., Owczarek, C. M., Akeret, K., Tester, A., Pereira, N., Butcher, R., Brügger-Verdon, V., Hardy, M. P., Illi, M., Wassmer, A., Vallelian, F., Humar, R., Hugelshofer, M., Buehler, P. W., Gentinetta, T., & Schaer, D. J. (2021). Modular Platform for the Development of Recombinant Hemoglobin Scavenger Biotherapeutics. Molecular Pharmaceutics, 18, 3158–3170. https://doi.org/10.1021/acs.molpharmaceut.1c00433
