Rapid adaptation to microgravity in mammalian macrophage cells

Thiel, Cora S; de Zélicourt, Diane; Tauber, Svantje; Adrian, Astrid; Franz, Markus; Simmet, Dana M; Schoppmann, Kathrin; Hauschild, Swantje; Krammer, Sonja; Christen, Miriam; Bradacs, Gesine; Paulsen, Katrin; Wolf, Susanne A; Braun, Markus; Hatton, Jason; Kurtcuoglu, Vartan; Franke, Stefanie; Tanner, Samuel; Cristoforetti, Samantha; Sick, Beate

doi:10.1038/s41598-017-00119-6

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Thiel, C. S., de Zélicourt, D., Tauber, S., Adrian, A., Franz, M., Simmet, D. M., Schoppmann, K., Hauschild, S., Krammer, S., Christen, M., Bradacs, G., Paulsen, K., Wolf, S. A., Braun, M., Hatton, J., Kurtcuoglu, V., Franke, S., Tanner, S., Cristoforetti, S., … Ullrich, O. (2017). Rapid adaptation to microgravity in mammalian macrophage cells. Scientific Reports, 7, 43. https://doi.org/10.1038/s41598-017-00119-6

Abstract

Despite the observed severe effects of microgravity on mammalian cells, many astronauts have completed long term stays in space without suffering from severe health problems. This raises questions about the cellular capacity for adaptation to a new gravitational environment. The International Space Station (ISS) experiment TRIPLE LUX A, performed in the BIOLAB laboratory of the ISS COLUMBUS module, allowed for the first time the direct measurement of a cellular function in real time and on orbit. We measured the oxidative burst reacti