Publication: Genetic deficiency in tissue kallikrein activity in mouse and man: effect on arteries, heart and kidney
Genetic deficiency in tissue kallikrein activity in mouse and man: effect on arteries, heart and kidney
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Pizard, A., Richer, C., Bouby, N., Picard, N., Meneton, P., Azizi, M., & Alhenc-Gelas, F. (2008). Genetic deficiency in tissue kallikrein activity in mouse and man: effect on arteries, heart and kidney. Biological Chemistry, 389(6), 701–706. https://doi.org/10.1515/BC.2008.081
Abstract
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Tissue kallikrein (KLK1) is a kinin-forming serine protease synthesized in many organs including arteries and kidney. Study of the physiological role of KLK1 has benefited from the availability of mouse and human genetic models of KLK1 deficiency, through engineering of KLK1 mouse mutants and discovery of a major polymorphism in the human KLK1 gene that induces a loss of enzyme activity. Studies in KLK1-deficient mice and human subjects partially deficient in KLK1 have documented its critical role in arterial function in both species.
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- Pizard, A
- Richer, C
- Bouby, N
- Picard, N
- Meneton, P
- Azizi, M
- Alhenc-Gelas, F
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Pizard, A., Richer, C., Bouby, N., Picard, N., Meneton, P., Azizi, M., & Alhenc-Gelas, F. (2008). Genetic deficiency in tissue kallikrein activity in mouse and man: effect on arteries, heart and kidney. Biological Chemistry, 389(6), 701–706. https://doi.org/10.1515/BC.2008.081
