Publication: The Influence of a Polyethylene Glycol Linker on the Metabolism and Pharmacokinetics of a 89Zr-Radiolabeled Antibody
The Influence of a Polyethylene Glycol Linker on the Metabolism and Pharmacokinetics of a 89Zr-Radiolabeled Antibody
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Guillou, A., Earley, D. F., Klingler, S., Nisli, E., Nüesch, L. J., Fay, R., & Holland, J. P. (2021). The Influence of a Polyethylene Glycol Linker on the Metabolism and Pharmacokinetics of a 89Zr-Radiolabeled Antibody. Bioconjugate Chemistry, 32(7), 1263–1275. https://doi.org/10.1021/acs.bioconjchem.1c00172
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Most experimental work in the space of bioconjugation chemistry focuses on using new methods to construct covalent bonds between a cargo molecule and a protein of interest such as a monoclonal antibody (mAb). Bond formation is important for generating new diagnostic tools, yet when these compounds advance to preclinical in vitro and in vivo studies, and later for translation to the clinic, understanding the fate of potential metabolites that arise from chemical or enzymatic degradation of the construct is important to obtain a full pi
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Creators (Authors)
- Guillou, Amaury
- Earley, Daniel F
- Klingler, Simon
- Nisli, Eda
- Nüesch, Laura J
- Fay, Rachael
- Holland, Jason P
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Citations
Guillou, A., Earley, D. F., Klingler, S., Nisli, E., Nüesch, L. J., Fay, R., & Holland, J. P. (2021). The Influence of a Polyethylene Glycol Linker on the Metabolism and Pharmacokinetics of a 89Zr-Radiolabeled Antibody. Bioconjugate Chemistry, 32(7), 1263–1275. https://doi.org/10.1021/acs.bioconjchem.1c00172
