Publication: Intravitreal AAV-Delivery of Genetically Encoded Sensors Enabling Simultaneous Two-Photon Imaging and Electrophysiology of Optic Nerve Axons
Intravitreal AAV-Delivery of Genetically Encoded Sensors Enabling Simultaneous Two-Photon Imaging and Electrophysiology of Optic Nerve Axons
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Looser, Z. J., Barrett, M. J. P., Hirrlinger, J., Weber, B., & Saab, A. S. (2018). Intravitreal AAV-Delivery of Genetically Encoded Sensors Enabling Simultaneous Two-Photon Imaging and Electrophysiology of Optic Nerve Axons. Frontiers in Cellular Neuroscience, 12, 2018.00377. https://doi.org/10.3389/fncel.2018.00377
Abstract
Abstract
Abstract
Myelination of axons by oligodendrocytes is a key feature of the remarkably fast operating CNS. Oligodendrocytes not only tune axonal conduction speed but are also suggested to maintain long-term axonal integrity by providing metabolic support to the axons they ensheath. However, how myelinating oligodendrocytes impact axonal energy homeostasis remains poorly understood and difficult to investigate. Here, we provide a method of how to study electrically active myelinated axons expressing genetically encoded sensors by combining electr
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- Looser, Zoe J
- Barrett, Matthew J P
- Hirrlinger, Johannes
- Weber, Bruno
- Saab, Aiman S
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Citations
Looser, Z. J., Barrett, M. J. P., Hirrlinger, J., Weber, B., & Saab, A. S. (2018). Intravitreal AAV-Delivery of Genetically Encoded Sensors Enabling Simultaneous Two-Photon Imaging and Electrophysiology of Optic Nerve Axons. Frontiers in Cellular Neuroscience, 12, 2018.00377. https://doi.org/10.3389/fncel.2018.00377
