Publication: Recombinant modified vaccinia virus Ankara generating Ebola virus-like particles
Recombinant modified vaccinia virus Ankara generating Ebola virus-like particles
Date
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Citations
Schweneker, M., Laimbacher, A. S., Zimmer, G., Wagner, S., Schraner, E. M., Wolferstätter, M., Klingenberg, M., Dirmeier, U., Steigerwald, R., Lauterbach, H., Hochrein, H., Chaplin, P., Suter, M., & Hausmann, J. (2017). Recombinant modified vaccinia virus Ankara generating Ebola virus-like particles. Journal of Virology, 91(11), e00343-17. https://doi.org/10.1128/JVI.00343-17
Abstract
Abstract
Abstract
There are currently no approved therapeutics or vaccines to treat or protect against the severe hemorrhagic fever and death caused by Ebola virus (EBOV). Ebola virus-like particles (EBOV VLPs) consisting of the matrix protein VP40, the glycoprotein (GP), and the nucleoprotein (NP) are highly immunogenic and protective in nonhuman primates against Ebola virus disease (EVD). We have constructed a modified vaccinia virus Ankara-Bavarian Nordic (MVA-BN) recombinant coexpressing VP40 and GP of EBOV Mayinga and the NP of Taï Forest virus (T
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Creators (Authors)
- Schweneker, Marc
- Laimbacher, Andrea S
- Zimmer, Gert
- Wagner, Susanne
- Schraner, Elisabeth M
- Wolferstätter, Michael
- Klingenberg, Marieken
- Dirmeier, Ulrike
- Steigerwald, Robin
- Lauterbach, Henning
- Hochrein, Hubertus
- Chaplin, Paul
- Suter, Mark
- Hausmann, Jürgen
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Citations
Schweneker, M., Laimbacher, A. S., Zimmer, G., Wagner, S., Schraner, E. M., Wolferstätter, M., Klingenberg, M., Dirmeier, U., Steigerwald, R., Lauterbach, H., Hochrein, H., Chaplin, P., Suter, M., & Hausmann, J. (2017). Recombinant modified vaccinia virus Ankara generating Ebola virus-like particles. Journal of Virology, 91(11), e00343-17. https://doi.org/10.1128/JVI.00343-17
