Publication: Notch signaling in the dynamics of perivascular stem cells and their niches
Notch signaling in the dynamics of perivascular stem cells and their niches
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Pagella, P., de Vargas Roditi, L., Stadlinger, B., Moor, A. E., & Mitsiadis, T. A. (2021). Notch signaling in the dynamics of perivascular stem cells and their niches. Stem Cells Translational Medicine, 10(10), 1433–1445. https://doi.org/10.1002/sctm.21-0086
Abstract
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Abstract
The Notch signaling pathway is a fundamental regulator of cell fate determination in homeostasis and regeneration. In this work, we aimed to determine how Notch signaling mediates the interactions between perivascular stem cells and their niches in human dental mesenchymal tissues, both in homeostatic and regenerative conditions. By single cell RNA sequencing analysis, we showed that perivascular cells across the dental pulp and periodontal human tissues all express NOTCH3, and that these cells are important for the response to trauma
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- Pagella, Pierfrancesco
- de Vargas Roditi, Laura
- Stadlinger, Bernd
- Moor, Andreas E
- Mitsiadis, Thimios A
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Pagella, P., de Vargas Roditi, L., Stadlinger, B., Moor, A. E., & Mitsiadis, T. A. (2021). Notch signaling in the dynamics of perivascular stem cells and their niches. Stem Cells Translational Medicine, 10(10), 1433–1445. https://doi.org/10.1002/sctm.21-0086
