Directing Stem Cell Commitment by Amorphous Calcium Phosphate Nanoparticles Incorporated in PLGA: Relevance of the Free Calcium Ion Concentration

Gröninger, Olivier; Hess, Samuel; Mohn, Dirk; Schneider, Elia; Stark, Wendelin; Märsmann, Sonja; Wolint, Petra; Calcagni, Maurizio; Cinelli, Paolo; Buschmann, Johanna

doi:10.3390/ijms21072627

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Gröninger, O., Hess, S., Mohn, D., Schneider, E., Stark, W., Märsmann, S., Wolint, P., Calcagni, M., Cinelli, P., & Buschmann, J. (2020). Directing Stem Cell Commitment by Amorphous Calcium Phosphate Nanoparticles Incorporated in PLGA: Relevance of the Free Calcium Ion Concentration. International Journal of Molecular Sciences, 21, 2627. https://doi.org/10.3390/ijms21072627

Abstract

The microenvironment of mesenchymal stem cells (MSCs) is responsible for the modulation in MSC commitment. Nanocomposites with an inorganic and an organic component have been investigated, and osteogenesis of MSCs has been attributed to inorganic phases such as calcium phosphate under several conditions. Here, electrospun meshes and two-dimensional films of poly(lactic-co-glycolic acid) (PLGA) or nanocomposites of PLGA and amorphous calcium phosphate nanoparticles (PLGA/aCaP) seeded with human adipose-derived stem cells (ASCs) were an