Publication: Whole-exome rare-variant analysis of Alzheimer's disease and related biomarker traits
Whole-exome rare-variant analysis of Alzheimer's disease and related biomarker traits
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Küçükali, F., Neumann, A., Van Dongen, J., et al, & Popp, J. (2023). Whole-exome rare-variant analysis of Alzheimer’s disease and related biomarker traits. Alzheimer’s & Dementia, 19, 2317–2331. https://doi.org/10.1002/alz.12842
Abstract
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Abstract
INTRODUCTION: Despite increasing evidence of a role of rare genetic variation in the risk of Alzheimer's disease (AD), limited attention has been paid to its contribution to AD-related biomarker traits indicative of AD-relevant pathophysiological processes.
METHODS: We performed whole-exome gene-based rare-variant association studies (RVASs) of 17 AD-related traits on whole-exome sequencing (WES) data generated in the European Medical Information Framework for Alzheimer's Disease Multimodal Biomarker Discovery (EMIF-AD MBD) study (n
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- Küçükali, Fahri
- Neumann, Alexander
- Van Dongen, Jasper
- Popp, Julius
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Küçükali, F., Neumann, A., Van Dongen, J., et al, & Popp, J. (2023). Whole-exome rare-variant analysis of Alzheimer’s disease and related biomarker traits. Alzheimer’s & Dementia, 19, 2317–2331. https://doi.org/10.1002/alz.12842
