Publication:
Biological evaluation of pyridone alkaloids on the endocannabinoid system

Date

Date

Date
2017
Journal Article
Published version

Abstract

Abstract

Abstract
Naturally occurring pyridone alkaloids as well as synthetic derivatives were previously shown to induce neurite outgrowth. However, the molecular basis for this biological effect remains poorly understood. In this work, we have prepared new pyridones, and tested the effect of thirteen 4-hydroxy-2-pyridone derivatives on the components of the endocannabinoid system. Investigation of binding affinities towards CB1 and CB2 receptors led to the identification of a compound binding selectively to CB1 (12). Compound 12 and a closely related

Additional indexing

Creators (Authors)

  • Chicca, Andrea
    affiliation.icon.alt
  • Berg, Regina
    affiliation.icon.alt
  • Jessen, Henning J
    affiliation.icon.alt
  • Marck, Nicolas
    affiliation.icon.alt
  • Schmid, Fabian
    affiliation.icon.alt
  • Burch, Patrick
    affiliation.icon.alt
  • Gertsch, Jürg
    affiliation.icon.alt
  • Gademann, Karl
    affiliation.icon.alt

Journal/Series Title

Journal/Series Title

Journal/Series Title

Volume

Volume

Volume
25

Number

Number

Number
22

Page range/Item number

Page range/Item number

Page range/Item number
6102

Page end

Page end

Page end
6114

Item Type

Item Type

Item Type
Journal Article

Dewey Decimal Classifikation

Dewey Decimal Classifikation

Dewey Decimal Classifikation

Language

Language

Language
English

Publication date

Publication date

Publication date
2017

Date available

Date available

Date available
2018-04-03

Publisher

Publisher

Publisher

ISSN or e-ISSN

ISSN or e-ISSN

ISSN or e-ISSN
0968-0896

OA Status

OA Status

OA Status
Green
Green Open Access
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Files

Files

Files
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Files

Files

Files
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