Publication: Biological evaluation of pyridone alkaloids on the endocannabinoid system
Date
Date
Date
2017
Journal Article
Published version
Abstract
Abstract
Abstract
Naturally occurring pyridone alkaloids as well as synthetic derivatives were previously shown to induce neurite outgrowth. However, the molecular basis for this biological effect remains poorly understood. In this work, we have prepared new pyridones, and tested the effect of thirteen 4-hydroxy-2-pyridone derivatives on the components of the endocannabinoid system. Investigation of binding affinities towards CB1 and CB2 receptors led to the identification of a compound binding selectively to CB1 (12). Compound 12 and a closely related
Additional indexing
Creators (Authors)
- Chicca, Andrea
- Berg, Regina
- Jessen, Henning J
- Marck, Nicolas
- Schmid, Fabian
- Burch, Patrick
- Gertsch, Jürg
- Gademann, Karl
Volume
Volume
Volume
25
Number
Number
Number
22
Page range/Item number
Page range/Item number
Page range/Item number
6102
Page end
Page end
Page end
6114
Item Type
Item Type
Item Type
Journal Article
In collections
Dewey Decimal Classifikation
Dewey Decimal Classifikation
Dewey Decimal Classifikation
Language
Language
Language
English
Publication date
Publication date
Publication date
2017
Date available
Date available
Date available
2018-04-03
ISSN or e-ISSN
ISSN or e-ISSN
ISSN or e-ISSN
0968-0896
OA Status
OA Status
OA Status
Green
Publisher DOI
Green Open Access
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Files
Files
Files
Files available to download:2
Files
Files
Files
Files available to download:2