Publication: TORC1-regulated protein kinase Npr1 phosphorylates Orm to stimulate complex sphingolipid synthesis
TORC1-regulated protein kinase Npr1 phosphorylates Orm to stimulate complex sphingolipid synthesis
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Shimobayashi, M., Oppliger, W., Moes, S., Jenö, P., & Hall, M. N. (2013). TORC1-regulated protein kinase Npr1 phosphorylates Orm to stimulate complex sphingolipid synthesis. Molecular Biology of the Cell, 24, 870–881. https://doi.org/10.1091/mbc.E12-10-0753
Abstract
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Abstract
The evolutionarily conserved Orm1 and Orm2 proteins mediate sphingolipid homeostasis. However, the homologous Orm proteins and the signaling pathways modulating their phosphorylation and function are incompletely characterized. Here we demonstrate that inhibition of nutrient-sensitive target of rapamycin complex 1 (TORC1) stimulates Orm phosphorylation and synthesis of complex sphingolipids in Saccharomyces cerevisiae. TORC1 inhibition activates the kinase Npr1 that directly phosphorylates and activates the Orm proteins. Npr1-phosphor
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- Shimobayashi, Mitsugu
- Oppliger, Wolfgang
- Moes, Suzette
- Jenö, Paul
- Hall, Michael N
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Shimobayashi, M., Oppliger, W., Moes, S., Jenö, P., & Hall, M. N. (2013). TORC1-regulated protein kinase Npr1 phosphorylates Orm to stimulate complex sphingolipid synthesis. Molecular Biology of the Cell, 24, 870–881. https://doi.org/10.1091/mbc.E12-10-0753
