Publication: Gliomatosis cerebri: no evidence for a separate brain tumor entity
Gliomatosis cerebri: no evidence for a separate brain tumor entity
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Herrlinger, U., Jones, D. T. W., Glas, M., Hattingen, E., Gramatzki, D., Stuplich, M., Felsberg, J., Bähr, O., Gielen, G. H., Simon, M., Wiewrodt, D., Schabet, M., Hovestadt, V., Capper, D., Steinbach, J. P., von Deimling, A., Lichter, P., Pfister, S. M., Weller, M., & Reifenberger, G. (2016). Gliomatosis cerebri: no evidence for a separate brain tumor entity. Acta Neuropathologica, 131(2), 309–319. https://doi.org/10.1007/s00401-015-1495-z
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Gliomatosis cerebri (GC) is presently considered a distinct astrocytic glioma entity according to the WHO classification for CNS tumors. It is characterized by widespread, typically bilateral infiltration of the brain involving three or more lobes. Genetic studies of GC have to date been restricted to the analysis of individual glioma-associated genes, which revealed mutations in the isocitrate dehydrogenase 1 (IDH1) and tumor protein p53 (TP53) genes in subsets of patients. Here, we report on a genome-wide analysis of DNA methylation
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Herrlinger, U., Jones, D. T. W., Glas, M., Hattingen, E., Gramatzki, D., Stuplich, M., Felsberg, J., Bähr, O., Gielen, G. H., Simon, M., Wiewrodt, D., Schabet, M., Hovestadt, V., Capper, D., Steinbach, J. P., von Deimling, A., Lichter, P., Pfister, S. M., Weller, M., & Reifenberger, G. (2016). Gliomatosis cerebri: no evidence for a separate brain tumor entity. Acta Neuropathologica, 131(2), 309–319. https://doi.org/10.1007/s00401-015-1495-z