Publication:

Gliomatosis cerebri: no evidence for a separate brain tumor entity

Date

Date

Date
2016
Journal Article
Published version

Citations

Citation copied

Herrlinger, U., Jones, D. T. W., Glas, M., Hattingen, E., Gramatzki, D., Stuplich, M., Felsberg, J., Bähr, O., Gielen, G. H., Simon, M., Wiewrodt, D., Schabet, M., Hovestadt, V., Capper, D., Steinbach, J. P., von Deimling, A., Lichter, P., Pfister, S. M., Weller, M., & Reifenberger, G. (2016). Gliomatosis cerebri: no evidence for a separate brain tumor entity. Acta Neuropathologica, 131(2), 309–319. https://doi.org/10.1007/s00401-015-1495-z

Abstract

Abstract

Abstract

Gliomatosis cerebri (GC) is presently considered a distinct astrocytic glioma entity according to the WHO classification for CNS tumors. It is characterized by widespread, typically bilateral infiltration of the brain involving three or more lobes. Genetic studies of GC have to date been restricted to the analysis of individual glioma-associated genes, which revealed mutations in the isocitrate dehydrogenase 1 (IDH1) and tumor protein p53 (TP53) genes in subsets of patients. Here, we report on a genome-wide analysis of DNA methylation

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621 since deposited on 2016-05-31
Acq. date: 2025-11-08

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550 since deposited on 2016-05-31
Acq. date: 2025-11-08

Additional indexing

Creators (Authors)

  • Herrlinger, Ulrich
    affiliation.icon.alt
  • Jones, David T W
    affiliation.icon.alt
  • Glas, Martin
    affiliation.icon.alt
  • Hattingen, Elke
    affiliation.icon.alt
  • Gramatzki, Dorothee
    affiliation.icon.alt
  • Stuplich, Moritz
    affiliation.icon.alt
  • Felsberg, Jörg
    affiliation.icon.alt
  • Bähr, Oliver
    affiliation.icon.alt
  • Gielen, Gerrit H
    affiliation.icon.alt
  • Simon, Matthias
    affiliation.icon.alt
  • Wiewrodt, Dorothee
    affiliation.icon.alt
  • Schabet, Martin
    affiliation.icon.alt
  • Hovestadt, Volker
    affiliation.icon.alt
  • Capper, David
    affiliation.icon.alt
  • Steinbach, Joachim P
    affiliation.icon.alt
  • von Deimling, Andreas
    affiliation.icon.alt
  • Lichter, Peter
    affiliation.icon.alt
  • Pfister, Stefan M
    affiliation.icon.alt
  • Weller, Michael
    affiliation.icon.alt
  • Reifenberger, Guido
    affiliation.icon.alt

Journal/Series Title

Journal/Series Title

Journal/Series Title

Volume

Volume

Volume
131

Number

Number

Number
2

Page Range

Page Range

Page Range
309

Page end

Page end

Page end
319

Item Type

Item Type

Item Type
Journal Article

Dewey Decimal Classifikation

Dewey Decimal Classifikation

Dewey Decimal Classifikation

Keywords

Gliomatosis cerebri, DNA methylation profiles, Genomic aberrations, IDH1 mutation, MGMT promoter methylation, Molecular classification

Language

Language

Language
English

Publication date

Publication date

Publication date
2016-02-01

Date available

Date available

Date available
2016-05-31

Publisher

Publisher

Publisher

ISSN or e-ISSN

ISSN or e-ISSN

ISSN or e-ISSN
0001-6322

Additional Information

Additional Information

Additional Information
The final publication is available at Springer via http://dx.doi.org/10.1007/s00401-015-1495-z

OA Status

OA Status

OA Status
Green

PubMed ID

PubMed ID

PubMed ID

Metrics

Downloads

621 since deposited on 2016-05-31
Acq. date: 2025-11-08

Views

550 since deposited on 2016-05-31
Acq. date: 2025-11-08

Citations

Citation copied

Herrlinger, U., Jones, D. T. W., Glas, M., Hattingen, E., Gramatzki, D., Stuplich, M., Felsberg, J., Bähr, O., Gielen, G. H., Simon, M., Wiewrodt, D., Schabet, M., Hovestadt, V., Capper, D., Steinbach, J. P., von Deimling, A., Lichter, P., Pfister, S. M., Weller, M., & Reifenberger, G. (2016). Gliomatosis cerebri: no evidence for a separate brain tumor entity. Acta Neuropathologica, 131(2), 309–319. https://doi.org/10.1007/s00401-015-1495-z

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