Protective coatings for intraocular wirelessly controlled microrobots for implantation: Corrosion, cell culture, andin vivoanimal tests

Pokki, Juho; Ergeneman, Olgaç; Chatzipirpiridis, George; Lühmann, Tessa; Sort, Jordi; Pellicer, Eva; Pot, Simon A; Spiess, Bernhard M; Pané, Salvador; Nelson, Bradley J

doi:10.1002/jbm.b.33618

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Pokki, J., Ergeneman, O., Chatzipirpiridis, G., Lühmann, T., Sort, J., Pellicer, E., Pot, S. A., Spiess, B. M., Pané, S., & Nelson, B. J. (2017). Protective coatings for intraocular wirelessly controlled microrobots for implantation: Corrosion, cell culture, andin vivoanimal tests. Journal of Biomedical Materials Research. Part B, 105(4), 836–845. https://doi.org/10.1002/jbm.b.33618

Abstract

Diseases in the ocular posterior segment are a leading cause of blindness. The surgical skills required to treat them are at the limits of human manipulation ability, and involve the risk of permanent retinal damage. Instrument tethering and design limit accessibility within the eye. Wireless microrobots suturelessly injected into the posterior segment, steered using magnetic manipulation are proposed for procedures involving implantation. Biocompatibility is a prerequisite for these procedures. This article investigates the use of po