Publication: p300-mediated acetylation of the Rothmund-Thomson-syndrome gene product RECQL4 regulates its subcellular localization
p300-mediated acetylation of the Rothmund-Thomson-syndrome gene product RECQL4 regulates its subcellular localization
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Dietschy, T., Shevelev, I., Pena-Diaz, J., Hühn, D., Kuenzle, S., Mak, R., Miah, M. F., Hess, D., Fey, M., Hottiger, M. O., Janscak, P., & Stagljar, I. (2009). p300-mediated acetylation of the Rothmund-Thomson-syndrome gene product RECQL4 regulates its subcellular localization. Journal of Cell Science, 122, 1258–1267. https://doi.org/10.1242/jcs.037747
Abstract
Abstract
Abstract
RECQL4 belongs to the conserved RecQ family of DNA helicases, members of which play important roles in the maintenance of genome stability in all organisms that have been examined. Although genetic alterations in the RECQL4 gene are reported to be associated with three autosomal recessive disorders (Rothmund-Thomson, RAPADILINO and Baller-Gerold syndromes), the molecular role of RECQL4 still remains poorly understood. Here, we show that RECQL4 specifically interacts with the histone acetyltransferase p300 (also known as p300 HAT), bot
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- Dietschy, T
- Shevelev, I
- Pena-Diaz, J
- Hühn, D
- Kuenzle, S
- Mak, R
- Miah, M F
- Hess, D
- Fey, M
- Hottiger, M O
- Janscak, Pavel
- Stagljar, I
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Dietschy, T., Shevelev, I., Pena-Diaz, J., Hühn, D., Kuenzle, S., Mak, R., Miah, M. F., Hess, D., Fey, M., Hottiger, M. O., Janscak, P., & Stagljar, I. (2009). p300-mediated acetylation of the Rothmund-Thomson-syndrome gene product RECQL4 regulates its subcellular localization. Journal of Cell Science, 122, 1258–1267. https://doi.org/10.1242/jcs.037747
