Comparative evaluation of the MAPlex, Precision ID Ancestry Panel, and VISAGE Basic Tool for biogeographical ancestry inference

Resutik, Peter; Aeschbacher, Simon; Krützen, Michael; Kratzer, Adelgunde; Haas, Cordula; Phillips, Christopher; Arora, Natasha

doi:10.1016/j.fsigen.2023.102850

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Resutik, P., Aeschbacher, S., Krützen, M., Kratzer, A., Haas, C., Phillips, C., & Arora, N. (2023). Comparative evaluation of the MAPlex, Precision ID Ancestry Panel, and VISAGE Basic Tool for biogeographical ancestry inference. Forensic Science International. Genetics, 64, 102850. https://doi.org/10.1016/j.fsigen.2023.102850

Abstract

Biogeographical ancestry (BGA) inference from ancestry-informative markers (AIMs) has strong potential to support forensic investigations. Over the past two decades, several forensic panels composed of AIMs have been developed to predict ancestry at a continental scale. These panels typically comprise fewer than 200 AIMs and have been designed and tested with a limited set of populations. How well these panels recover patterns of genetic diversity relative to larger sets of markers, and how accurately they infer ancestry of individual