Publication: Protein tyrosine phosphatase non-receptor type 2 controls colorectal cancer development
Protein tyrosine phosphatase non-receptor type 2 controls colorectal cancer development
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Katkeviciute, E., Hering, L., Montalban-Arques, A., Busenhart, P., Schwarzfischer, M., Manzini, R., Conde, J., Atrott, K., Lang, S., Rogler, G., Naschberger, E., Schellerer, V. S., Stürzl, M., Rickenbacher, A., Turina, M., Weber, A., Leibl, S., Leventhal, G. E., Levesque, M. P., … Spalinger, M. R. (2021). Protein tyrosine phosphatase non-receptor type 2 controls colorectal cancer development. Journal of Clinical Investigation, 131, e140281. https://doi.org/10.1172/JCI140281
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Protein tyrosine phosphatase non-receptor type 2 (PTPN2) recently emerged as a promising cancer immunotherapy target. We set to investigate the functional role of PTPN2 in the pathogenesis of human colorectal carcinoma (CRC) as its role in immune-silent solid tumors is poorly understood. We demonstrate that in human CRC, increased PTPN2 expression and activity correlated with disease progression and decreased immune responses in tumor tissues. Particularly, stage II and III tumors displayed enhanced PTPN2 protein expression in tumor-i
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Katkeviciute, E., Hering, L., Montalban-Arques, A., Busenhart, P., Schwarzfischer, M., Manzini, R., Conde, J., Atrott, K., Lang, S., Rogler, G., Naschberger, E., Schellerer, V. S., Stürzl, M., Rickenbacher, A., Turina, M., Weber, A., Leibl, S., Leventhal, G. E., Levesque, M. P., … Spalinger, M. R. (2021). Protein tyrosine phosphatase non-receptor type 2 controls colorectal cancer development. Journal of Clinical Investigation, 131, e140281. https://doi.org/10.1172/JCI140281
