Publication: Extracellular hemoglobin polarizes the macrophage proteome toward Hb-clearance, enhanced antioxidant capacity and suppressed HLA class 2 expression
Extracellular hemoglobin polarizes the macrophage proteome toward Hb-clearance, enhanced antioxidant capacity and suppressed HLA class 2 expression
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Kaempfer, T., Duerst, E., Gehrig, P., Roschitzki, B., Rutishauser, D., Grossmann, J., Schoedon, G., Vallelian, F., & Schaer, D. J. (2011). Extracellular hemoglobin polarizes the macrophage proteome toward Hb-clearance, enhanced antioxidant capacity and suppressed HLA class 2 expression. Journal of Proteome Research, 10, 2397–2408. https://doi.org/10.1021/pr101230y
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Peripheral blood monocytes and macrophages are the only cell population with a proven hemoglobin (Hb) clearance capacity through the CD163 scavenger receptor pathway. Hb detoxification and related adaptive cellular responses are assumed to be essential processes to maintaining tissue homeostasis and promoting wound healing in injured tissues. Using a dual platform mass spectrometry analysis with MALDI-TOF/TOF and LTQ-Orbitrap instruments combined with isobaric tag for relative and absolute quantitation (iTRAQ), we analyzed how Hb expo
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- Kaempfer, T
- Duerst, E
- Gehrig, P
- Roschitzki, B
- Rutishauser, D
- Grossmann, J
- Schoedon, G
- Vallelian, F
- Schaer, D J
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Kaempfer, T., Duerst, E., Gehrig, P., Roschitzki, B., Rutishauser, D., Grossmann, J., Schoedon, G., Vallelian, F., & Schaer, D. J. (2011). Extracellular hemoglobin polarizes the macrophage proteome toward Hb-clearance, enhanced antioxidant capacity and suppressed HLA class 2 expression. Journal of Proteome Research, 10, 2397–2408. https://doi.org/10.1021/pr101230y