Publication: Molecular determinants of transport function in zebrafish Slc34a Na-phosphate transporters
Molecular determinants of transport function in zebrafish Slc34a Na-phosphate transporters
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Werner, A., Patti, M., Zinad, H. S., Fearn, A., Laude, A., & Forster, I. (2016). Molecular determinants of transport function in zebrafish Slc34a Na-phosphate transporters. American Journal of Physiology. Regulatory, Integrative and Comparative Physiology, 311(6), R1213–R1222. https://doi.org/10.1152/ajpregu.00020.2016
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The epithelial Na(+)-coupled phosphate cotransporter family Slc34a (NaPi-II) is well conserved in vertebrates and plays an essential role in maintaining whole body levels of inorganic phosphate (Pi). A three-dimensional model of the transport protein has recently been proposed with defined substrate coordination sites. Zebrafish express two NaPi-II isoforms with high sequence identity but a 10-fold different apparent Km for Pi ([Formula: see text]). We took advantage of the two zebrafish isoforms to investigate the contribution of spe
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- Werner, Andreas
- Patti, Monica
- Zinad, Hany S
- Fearn, Amy
- Laude, Alex
- Forster, Ian
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Werner, A., Patti, M., Zinad, H. S., Fearn, A., Laude, A., & Forster, I. (2016). Molecular determinants of transport function in zebrafish Slc34a Na-phosphate transporters. American Journal of Physiology. Regulatory, Integrative and Comparative Physiology, 311(6), R1213–R1222. https://doi.org/10.1152/ajpregu.00020.2016
