Publication: Bidirectional regulation of distinct memory domains by α5-subunit-containing GABA$_{A}$ receptors in CA1 pyramidal neurons
Bidirectional regulation of distinct memory domains by α5-subunit-containing GABA$_{A}$ receptors in CA1 pyramidal neurons
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Engin, E., Sigal, M., Benke, D., Zeller, A., & Rudolph, U. (2020). Bidirectional regulation of distinct memory domains by α5-subunit-containing GABA$_{A}$ receptors in CA1 pyramidal neurons. Learning & Memory, 27, 423–428. https://doi.org/10.1101/lm.052084.120
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Abstract
Reduction in the expression or function of α5-subunit-containing GABAA receptors (α5GABAARs) leads to improvement in several hippocampus-dependent memory domains. However, studies thus far mostly lack anatomical specificity in terms of neuronal circuits and populations. We demonstrate that mice with a selective knockdown of α5GABAARs in CA1 pyramidal neurons (α5CA1KO mice) show improved spatial and trace fear-conditioning memory. Unexpectedly, α5CA1KO mice were comparable to controls in contextual fear-conditioning but showed an impai
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- Engin, Elif
- Sigal, Maksim
- Benke, Dietmar
- Zeller, Anja
- Rudolph, Uwe
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Engin, E., Sigal, M., Benke, D., Zeller, A., & Rudolph, U. (2020). Bidirectional regulation of distinct memory domains by α5-subunit-containing GABA$_{A}$ receptors in CA1 pyramidal neurons. Learning & Memory, 27, 423–428. https://doi.org/10.1101/lm.052084.120
