Alveolar macrophages rely on GM-CSF from alveolar epithelial type 2 cells before and after birth

Gschwend, Julia; Sherman, Samantha P M; Ridder, Frederike; Feng, Xiaogang; Liang, Hong-Erh; Locksley, Richard M; Becher, Burkhard; Schneider, Christoph

doi:10.1084/jem.20210745

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Gschwend, J., Sherman, S. P. M., Ridder, F., Feng, X., Liang, H.-E., Locksley, R. M., Becher, B., & Schneider, C. (2021). Alveolar macrophages rely on GM-CSF from alveolar epithelial type 2 cells before and after birth. Journal of Experimental Medicine, 218(10), :e20210745. https://doi.org/10.1084/jem.20210745

Abstract

Programs defining tissue-resident macrophage identity depend on local environmental cues. For alveolar macrophages (AMs), these signals are provided by immune and nonimmune cells and include GM-CSF (CSF2). However, evidence to functionally link components of this intercellular cross talk remains scarce. We thus developed new transgenic mice to profile pulmonary GM-CSF expression, which we detected in both immune cells, including group 2 innate lymphoid cells and γδ T cells, as well as AT2s. AMs were unaffected by constitutive deletion