Publication: The CUL4B‐based E3 ubiquitin ligase regulates mitosis and brain development by recruiting phospho‐specific DCAFs
The CUL4B‐based E3 ubiquitin ligase regulates mitosis and brain development by recruiting phospho‐specific DCAFs
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Stier, A., Gilberto, S., Mohamed, W. I., Royall, L. N., Helenius, J., Mikicic, I., Sajic, T., Beli, P., Müller, D. J., Jessberger, S., & Peter, M. (2023). The CUL4B‐based E3 ubiquitin ligase regulates mitosis and brain development by recruiting phospho‐specific DCAFs. The EMBO Journal, 42(17), e112847. https://doi.org/10.15252/embj.2022112847
Abstract
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The paralogs CUL4A and CUL4B assemble cullin‐RING E3 ubiquitin ligase (CRL) complexes regulating multiple chromatin‐associated cellular functions. Although they are structurally similar, we found that the unique N‐terminal extension of CUL4B is heavily phosphorylated during mitosis, and the phosphorylation pattern is perturbed in the CUL4B‐P50L mutation causing X‐linked intellectual disability (XLID). Phenotypic characterization and mutational analysis revealed that CUL4B phosphorylation is required for efficient progression through m
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- Stier, Anna
- Gilberto, Samuel
- Mohamed, Weaam I
- Royall, Lars N
- Helenius, Jonne
- Mikicic, Ivan
- Sajic, Tatjana
- Beli, Petra
- Müller, Daniel J
- Jessberger, Sebastian
- Peter, Matthias
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Stier, A., Gilberto, S., Mohamed, W. I., Royall, L. N., Helenius, J., Mikicic, I., Sajic, T., Beli, P., Müller, D. J., Jessberger, S., & Peter, M. (2023). The CUL4B‐based E3 ubiquitin ligase regulates mitosis and brain development by recruiting phospho‐specific DCAFs. The EMBO Journal, 42(17), e112847. https://doi.org/10.15252/embj.2022112847
