Publication: Broadening the Utility of Farnesyltransferase-Catalyzed Protein Labeling Using Norbornene-Tetrazine Click Chemistry
Broadening the Utility of Farnesyltransferase-Catalyzed Protein Labeling Using Norbornene-Tetrazine Click Chemistry
Date
Date
Date
Citations
Auger, S. A., Venkatachalapathy, S., Suazo, K. F. G., Wang, Y., Sarkis, A. W., Bernhagen, K., Justyna, K., Schaefer, J. V., Wollack, J. W., Plückthun, A., Li, L., & Distefano, M. D. (2024). Broadening the Utility of Farnesyltransferase-Catalyzed Protein Labeling Using Norbornene-Tetrazine Click Chemistry. Bioconjugate Chemistry, 35(7), 922–933. https://doi.org/10.1021/acs.bioconjchem.4c00072
Abstract
Abstract
Abstract
Bioorthogonal chemistry has gained widespread use in the study of many biological systems of interest, including protein prenylation. Prenylation is a post-translational modification, in which one or two 15- or 20-carbon isoprenoid chains are transferred onto cysteine residues near the C-terminus of a target protein. The three main enzymes─protein farnesyltransferase (FTase), geranylgeranyl transferase I (GGTase I), and geranylgeranyl transferase II (GGTase II)─that catalyze this process have been shown to tolerate numerous structural
Metrics
Downloads
Views
Additional indexing
Creators (Authors)
- Auger, Shelby A
- Venkatachalapathy, Sneha
- Suazo, Kiall Francis G
- Wang, Yiao
- Sarkis, Alexander W
- Bernhagen, Kaitlyn
- Justyna, Katarzyna
- Schaefer, Jonas V
- Wollack, James W
- Li, Ling
- Distefano, Mark D
Volume
Volume
Volume
Number
Number
Number
Page range/Item number
Page range/Item number
Page range/Item number
Page end
Page end
Page end
Item Type
Item Type
Item Type
Dewey Decimal Classifikation
Dewey Decimal Classifikation
Dewey Decimal Classifikation
Language
Language
Language
Publication date
Publication date
Publication date
Date available
Date available
Date available
ISSN or e-ISSN
ISSN or e-ISSN
ISSN or e-ISSN
OA Status
OA Status
OA Status
Publisher DOI
Metrics
Downloads
Views
Citations
Auger, S. A., Venkatachalapathy, S., Suazo, K. F. G., Wang, Y., Sarkis, A. W., Bernhagen, K., Justyna, K., Schaefer, J. V., Wollack, J. W., Plückthun, A., Li, L., & Distefano, M. D. (2024). Broadening the Utility of Farnesyltransferase-Catalyzed Protein Labeling Using Norbornene-Tetrazine Click Chemistry. Bioconjugate Chemistry, 35(7), 922–933. https://doi.org/10.1021/acs.bioconjchem.4c00072
