Publication: Hypothermia versus Normothermia after Out-of-Hospital Cardiac Arrest
Hypothermia versus Normothermia after Out-of-Hospital Cardiac Arrest
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Dankiewicz, J., Cronberg, T., Lilja, G., Jakobsen, J. C., Levin, H., Ullén, S., Rylander, C., Wise, M. P., Oddo, M., Cariou, A., Bělohlávek, J., & Hovdenes, J. (2021). Hypothermia versus Normothermia after Out-of-Hospital Cardiac Arrest. New England Journal of Medicine, 384(24), 2283–2294. https://doi.org/10.1056/nejmoa2100591
Abstract
Abstract
Abstract
Background: Targeted temperature management is recommended for patients after cardiac arrest, but the supporting evidence is of low certainty.
Methods: In an open-label trial with blinded assessment of outcomes, we randomly assigned 1900 adults with coma who had had an out-of-hospital cardiac arrest of presumed cardiac or unknown cause to undergo targeted hypothermia at 33°C, followed by controlled rewarming, or targeted normothermia with early treatment of fever (body temperature, ≥37.8°C). The primary outcome was death from any cau
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Creators (Authors)
- Dankiewicz, Josef
- Cronberg, Tobias
- Lilja, Gisela
- Jakobsen, Janus C
- Levin, Helena
- Ullén, Susann
- Rylander, Christian
- Wise, Matt P
- Oddo, Mauro
- Cariou, Alain
- Bělohlávek, Jan
- Hovdenes, Jan
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Hans-Gabriel och Alice Trolle-Wachtmeisters stiftelse för medicinsk forskning
Laerdal Foundation for Acute Medicine
Regional Grants, Skåne County Council, Sweden
Grants within the Swedish National Health Services
Stig and Ragna Gorthon Foundation
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Dankiewicz, J., Cronberg, T., Lilja, G., Jakobsen, J. C., Levin, H., Ullén, S., Rylander, C., Wise, M. P., Oddo, M., Cariou, A., Bělohlávek, J., & Hovdenes, J. (2021). Hypothermia versus Normothermia after Out-of-Hospital Cardiac Arrest. New England Journal of Medicine, 384(24), 2283–2294. https://doi.org/10.1056/nejmoa2100591
