Aqueous syntheses of [(Cp-R)M(CO)3] type complexes (Cp = cyclopentadienyl, M = Mn, 99mTc, Re) with bioactive functionalities

Peindy N'Dongo, H W; Liu, Y; Can, D; Schmutz, P; Spingler, B; Alberto, R

doi:10.5167/uzh-19382

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Peindy N’Dongo, H. W., Liu, Y., Can, D., Schmutz, P., Spingler, B., & Alberto, R. (2009). Aqueous syntheses of [(Cp-R)M(CO)3] type complexes (Cp = cyclopentadienyl, M = Mn, 99mTc, Re) with bioactive functionalities. Journal of Organometallic Chemistry, 694, 981–987. https://doi.org/10.1016/j.jorganchem.2008.12.006

Abstract

We describe reactions of [99mTc(H2O)3(CO)3)]+ (1) with Diels–Alder products of cyclopentadiene such as “Thiele’s acid” (HCp-COOH)2 (2) and derivatives thereof in which the corresponding [(Cp-COOH)99mTc(CO)3)] (3) complex did form in water. We propose a metal mediated Diels–Alder reaction mechanism. To show that this reaction was not limited to carboxylate groups, we synthesized conjugates of 2 (HCp-CONHR)2 (4a–c) (4a, R = benzyl amine; 4b, R = Nα-Boc-l-2,3-diaminopropionic acid and 4c, R = glycine). The corresponding 99mTc complexes [