Publication: Enzymatically Crosslinked Collagen as a Versatile Matrix for In Vitro and In Vivo Co‐Engineering of Blood and Lymphatic Vasculature
Enzymatically Crosslinked Collagen as a Versatile Matrix for In Vitro and In Vivo Co‐Engineering of Blood and Lymphatic Vasculature
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Rütsche, D., Nanni, M., Rüdisser, S., Biedermann, T., & Zenobi‐Wong, M. (2023). Enzymatically Crosslinked Collagen as a Versatile Matrix for In Vitro and In Vivo Co‐Engineering of Blood and Lymphatic Vasculature. Advanced Materials, 35(16), e2209476. https://doi.org/10.1002/adma.202209476
Abstract
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Abstract
Adequate vascularization is required for the successful translation of many in vitro engineered tissues. This study presents a novel collagen derivative that harbors multiple recognition peptides for orthogonal enzymatic crosslinking based on sortase A (SrtA) and Factor XIII (FXIII). SrtA-mediated crosslinking enables the rapid co-engineering of human blood and lymphatic microcapillaries and mesoscale capillaries in bulk hydrogels. Whereas tuning of gel stiffness determines the extent of neovascularization, the relative number of bloo
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- Rütsche, Dominic
- Nanni, Monica
- Rüdisser, Simon
- Biedermann, Thomas
- Zenobi‐Wong, Marcy
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Rütsche, D., Nanni, M., Rüdisser, S., Biedermann, T., & Zenobi‐Wong, M. (2023). Enzymatically Crosslinked Collagen as a Versatile Matrix for In Vitro and In Vivo Co‐Engineering of Blood and Lymphatic Vasculature. Advanced Materials, 35(16), e2209476. https://doi.org/10.1002/adma.202209476
