Publication: The Bloom's syndrome helicase promotes the annealing of complementary single-stranded DNA
The Bloom's syndrome helicase promotes the annealing of complementary single-stranded DNA
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Cheok, C. F., Wu, L., Garcia, P. L., Janscak, P., & Hickson, I. D. (2005). The Bloom’s syndrome helicase promotes the annealing of complementary single-stranded DNA. Nucleic Acids Research, 33, 3932–3941. https://doi.org/10.1093/nar/gki712
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Abstract
The product of the gene mutated in Bloom's syndrome, BLM, is a 3'-5' DNA helicase belonging to the highly conserved RecQ family. In addition to a conventional DNA strand separation activity, BLM catalyzes both the disruption of non-B-form DNA, such as G-quadruplexes, and the branch migration of Holliday junctions. Here, we have characterized a new activity for BLM: the promotion of single-stranded DNA (ssDNA) annealing. This activity does not require Mg(2+), is inhibited by ssDNA binding proteins and ATP, and is dependent on DNA lengt
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- Cheok, C F
- Wu, L
- Garcia, P L
- Janscak, Pavel
- Hickson, I D
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Cheok, C. F., Wu, L., Garcia, P. L., Janscak, P., & Hickson, I. D. (2005). The Bloom’s syndrome helicase promotes the annealing of complementary single-stranded DNA. Nucleic Acids Research, 33, 3932–3941. https://doi.org/10.1093/nar/gki712
