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Genome-wide association analyses of individual differences in quantitatively assessed reading- and language-related skills in up to 34,000 people

Date

Date

Date
2021
Working Paper

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Eising, E., Mirza-Schreiber, N., de Zeeuw, E. L., Wang, C. A., Truong, D. T., Allegrini, A. G., Shapland, C. Y., Zhu, G., Wigg, K. G., Gerritse, M., Molz, B., Alagöz, G., Gialluisi, A., Abbondanza, F., Rimfeld, K., van Donkelaar, M., Liao, Z., Jansen, P. R., Andlauer, T. F. M., … et al. (2021). Genome-wide association analyses of individual differences in quantitatively assessed reading- and language-related skills in up to 34,000 people (No. 466897; BioRxiv). https://doi.org/10.1101/2021.11.04.466897

Abstract

Abstract

Abstract

The use of spoken and written language is a capacity that is unique to humans. Individual differences in reading- and language-related skills are influenced by genetic variation, with twin-based heritability estimates of 30-80%, depending on the trait. The relevant genetic architecture is complex, heterogeneous, and multifactorial, and yet to be investigated with well-powered studies. Here, we present a multicohort genome-wide association study (GWAS) of five traits assessed individually using psychometric measures: word reading, nonw

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55 since deposited on 2022-02-10
Acq. date: 2025-11-12

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77 since deposited on 2022-02-10
Acq. date: 2025-11-12

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Creators (Authors)

  • Eising, Else
  • Mirza-Schreiber, Nazanin
  • de Zeeuw, Eveline L
  • Wang, Carol A
  • Truong, Dongnhu T
  • Allegrini, Andrea G
  • Shapland, Chin Yang
  • Zhu, Gu
  • Wigg, Karen G
  • Gerritse, Margot
  • Molz, Barbara
  • Alagöz, Gökberk
  • Gialluisi, Alessandro
  • Abbondanza, Filippo
  • Rimfeld, Kaili
  • van Donkelaar, Marjolein
  • Liao, Zhijie
  • Jansen, Philip R
  • Andlauer, Till F M
  • Bates, Timothy C
  • Bernard, Manon
  • Blokland, Kirsten
  • Børglum, Anders D
  • Bourgeron, Thomas
  • Brandeis, Daniel
  • Ceroni, Fabiola
  • Dale, Philip S
  • Landerl, Karin
  • Lyytinen, Heikki
  • de Jong, Peter F
  • et al

Series Name

Series Name

Series Name
bioRxiv

Institution

Institution

Institution

Item Type

Item Type

Item Type
Working Paper

Dewey Decimal Classifikation

Dewey Decimal Classifikation

Dewey Decimal Classifikation

Language

Language

Language
English

Publication date

Publication date

Publication date
2021-11-04

Date available

Date available

Date available
2022-02-10

ISSN or e-ISSN

ISSN or e-ISSN

ISSN or e-ISSN
2164-7844

OA Status

OA Status

OA Status
Green

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Downloads

55 since deposited on 2022-02-10
Acq. date: 2025-11-12

Views

77 since deposited on 2022-02-10
Acq. date: 2025-11-12

Citations

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Citation copied

Eising, E., Mirza-Schreiber, N., de Zeeuw, E. L., Wang, C. A., Truong, D. T., Allegrini, A. G., Shapland, C. Y., Zhu, G., Wigg, K. G., Gerritse, M., Molz, B., Alagöz, G., Gialluisi, A., Abbondanza, F., Rimfeld, K., van Donkelaar, M., Liao, Z., Jansen, P. R., Andlauer, T. F. M., … et al. (2021). Genome-wide association analyses of individual differences in quantitatively assessed reading- and language-related skills in up to 34,000 people (No. 466897; BioRxiv). https://doi.org/10.1101/2021.11.04.466897

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