Publication: The heat shock protein 83 (Hsp83) is required for Raf-mediated signalling in Drosophila.
The heat shock protein 83 (Hsp83) is required for Raf-mediated signalling in Drosophila.
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van der Straten, A., Rommel, C., Dickson, B. J., & Hafen, E. (1997). The heat shock protein 83 (Hsp83) is required for Raf-mediated signalling in Drosophila. The EMBO Journal, 16(8), 1961–1969. https://doi.org/10.1093/emboj/16.8.1961
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The heat shock protein Hsp90 has been shown to associate with various cellular signalling proteins such as steroid hormone receptors, src-like kinases and the serine/threonine kinase Raf. While the interaction between steroid hormone receptors and Hsp90 appears to be essential for ligand binding and activation of the receptors, the role of Hsp90 in Raf activation is less clear. We have identified mutations in the hsp83 gene, the Drosophila homologue of hsp90, in a search for dominant mutations that attenuate signalling from Raf in the
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- van der Straten, A
- Rommel, C
- Hafen, E
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van der Straten, A., Rommel, C., Dickson, B. J., & Hafen, E. (1997). The heat shock protein 83 (Hsp83) is required for Raf-mediated signalling in Drosophila. The EMBO Journal, 16(8), 1961–1969. https://doi.org/10.1093/emboj/16.8.1961
