Publication: Efficacy of finerenone in patients with type 2 diabetes, chronic kidney disease and altered markers of liver steatosis and fibrosis: A FIDELITY subgroup analysis
Efficacy of finerenone in patients with type 2 diabetes, chronic kidney disease and altered markers of liver steatosis and fibrosis: A FIDELITY subgroup analysis
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Perakakis, N., Bornstein, S. R., Birkenfeld, A. L., Linkermann, A., Demir, M., Anker, S. D., Filippatos, G., Pitt, B., Rossing, P., Ruilope, L. M., Kolkhof, P., Lawatscheck, R., Scott, C., Bakris, G. L., & FIDELIO-DKD and FIGARO-DKD investigators. (2024). Efficacy of finerenone in patients with type 2 diabetes, chronic kidney disease and altered markers of liver steatosis and fibrosis: A FIDELITY subgroup analysis. Diabetes, Obesity & Metabolism, 26(1), 191–200. https://doi.org/10.1111/dom.15305
Abstract
Abstract
Abstract
AIM
Investigating the effect of finerenone on liver function, cardiovascular and kidney composite outcomes in patients with chronic kidney disease and type 2 diabetes, stratified by their risk of liver steatosis, inflammation and fibrosis.
MATERIALS AND METHODS
Post hoc analysis stratified patients (N = 13 026) by liver fibrosis and enzymes: high risk of steatosis (hepatic steatosis index >36); elevated transaminases [alanine transaminase (ALT) >33 (males) and >25 IU/L (females)]; and fibrosis-4 (FIB-4) index scores >3.25, >2.67 an
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Creators (Authors)
- Perakakis, Nikolaos
- Bornstein, Stefan R
- Birkenfeld, Andreas L
- Linkermann, Andreas
- Demir, Münevver
- Anker, Stefan D
- Filippatos, Gerasimos
- Pitt, Bertram
- Rossing, Peter
- Ruilope, Luis M
- Kolkhof, Peter
- Lawatscheck, Robert
- Scott, Charlie
- Bakris, George L
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Perakakis, N., Bornstein, S. R., Birkenfeld, A. L., Linkermann, A., Demir, M., Anker, S. D., Filippatos, G., Pitt, B., Rossing, P., Ruilope, L. M., Kolkhof, P., Lawatscheck, R., Scott, C., Bakris, G. L., & FIDELIO-DKD and FIGARO-DKD investigators. (2024). Efficacy of finerenone in patients with type 2 diabetes, chronic kidney disease and altered markers of liver steatosis and fibrosis: A FIDELITY subgroup analysis. Diabetes, Obesity & Metabolism, 26(1), 191–200. https://doi.org/10.1111/dom.15305
