Dynamic and accurate assessment of acetaminophen-induced hepatotoxicity by integrated photoacoustic imaging and mechanistic biomarkers in vivo

Brillant, Nathalie; Elmasry, Mohamed; Burton, Neal C; Rodriguez, Josep Monne; Sharkey, Jack W; Fenwick, Stephen; Poptani, Harish; Kitteringham, Neil R; Goldring, Christopher E; Kipar, Anja; Kevin Park, B; Antoine, Daniel J

doi:10.1016/j.taap.2017.07.019

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Brillant, N., Elmasry, M., Burton, N. C., Rodriguez, J. M., Sharkey, J. W., Fenwick, S., Poptani, H., Kitteringham, N. R., Goldring, C. E., Kipar, A., Kevin Park, B., & Antoine, D. J. (2017). Dynamic and accurate assessment of acetaminophen-induced hepatotoxicity by integrated photoacoustic imaging and mechanistic biomarkers in vivo. Toxicology and Applied Pharmacology, 332, 64–74. https://doi.org/10.1016/j.taap.2017.07.019

Abstract

The prediction and understanding of acetaminophen (APAP)-induced liver injury (APAP-ILI) and the response to therapeutic interventions is complex. This is due in part to sensitivity and specificity limitations of currently used assessment techniques. Here we sought to determine the utility of integrating translational non-invasive photoacoustic imaging of liver function with mechanistic circulating biomarkers of hepatotoxicity with histological assessment to facilitate the more accurate and precise characterization of APAP-ILI and the